One of the first things you discover when you start investigating nutritional therapy is that vitamin B-complex formulations are badly designed. Never mind the dubious value of having most of the B vitamins in the same milligram amounts when no one can really say just what ratio they should ideally exist in. (Here’s a chart by Ronald Roth at Acu-cell.com illustrating the unbalancing effect that causes.) And never mind the fact that the majority of the complexes use forms of the vitamins that really don’t work well in people with stressed or overworked livers — cobalamin instead of methylcobalamin, folic acid instead of methylfolate, and pyridoxine instead of P5P (two types of vitamin B6). And what livers among us these days are not stressed and overworked?
The biggest problem with B-complex preparations is that to save on costs manufacturers seriously shortchange you on the more expensive biotin, vitamin B12, and folate. Typically only the US RDA amount is provided, which is pointless. 400 mcg of vitamin B12, only 3% of which is absorbed, will not do much for anyone.
If you rely on vitamin B-complex for a long period of time without taking additional B12, folate, and biotin supplements, you’ll eventually induce a deficiency of them. The extra, larger amounts of the other B vitamins, all of which work together and need each other to be processed, now have increased the need for that vitamin and you’re drawing on more of it than you were before you were taking the supplement. If you’re given a ton of one but too little of another, eventually those bigger doses will require too much of the lower doses.
I experienced this effect in a dramatic fashion when in an attempt to combat fatigue I decided to try 300 mg of vitamin B-complex a day, which is advocated in some circles as a fast way to get B vitamin levels up in situations where they are presumably very low — newly diagnosed celiacs for example, or recovering schizophrenics.
At the time, I was reading what someone had recommended as one of the best American detective novels ever, The Death of the Detective by Mark Smith. As it turned out, the book made the post-apocalyptic Children of Men look uplifting by comparison, and it didn’t even involve an apocalypse. As I read it, each menacing, creepy scene created stronger feelings of dread and anxiety. Paranoia carried over into my other activities — driving a car, walking around a store, etc. When I started shaking while reading one scene, it occurred to me that this probably wasn’t a normal reaction.
I figured the best culprit was the recent megadose experiment. I had taken extra vitamin B12 and biotin for a long time so I thought folic acid was probably the problem. I took 2 or 3 800 mcg methylfolate supplements and in about an hour was noticeably more relaxed.
I tossed the book without finishing it. Luckily for the author I couldn’t track him down. I was denied the satisfaction of sending him hate mail or hate tweets or some other social media hatefulness about his soul-sucking piece of crap.
Illustration: Gloria Swanson in Sunset Blvd., Paramount Pictures 1950. Remix by MRhea.